Journal article
Genetic variation in UGT genes modify the associations of NSAIDs with risk of colorectal cancer: Colon cancer family registry
D Scherer, LM Koepl, EM Poole, Y Balavarca, L Xiao, JA Baron, L Hsu, AE Coghill, PT Campbell, SE Kleinstein, JC Figueiredo, JW Lampe, K Buck, JD Potter, RJ Kulmacz, MA Jenkins, JL Hopper, AK Win, PA Newcomb, CM Ulrich Show all
Genes Chromosomes and Cancer | WILEY | Published : 2014
DOI: 10.1002/gcc.22167
Abstract
The use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with reduced risk of colorectal neoplasia. Previous studies have reported that polymorphisms in NSAID-metabolizing enzymes central to NSAID metabolism including UDP-glucuronosyltransferases (UGT) and cytochrome P450 (CYP) 2C9 may modify this protective effect. We investigated whether 35 functionally relevant polymorphisms within CYP2C9 and UGT genes were associated with colorectal cancer risk or modified the protective effect of NSAIDs on colorectal cancer susceptibility, using 1,584 colorectal cancer cases and 2,516 unaffected sibling controls from the Colon Cancer Family Registry. A three-SNP genotype in UGT1A6 (G-A-A;..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by the National Cancer Institute, National Institutes of Health under RFA # CA-95-011 and through cooperative agreements with members of the Colon Cancer Family Registry (CCFR) and Principal Investigators. The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centers in the CFRs, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government or the CFR. CFR centers providing data for the analysis include: Australasian Colorectal Cancer Family Registry (U01 CA097735); Familial Colorectal Neoplasia Collaborative Group (U01 CA074799); Mayo Clinic Cooperative Family Registry for Colon Cancer Studies (U01 CA074800); Ontario Registry for Studies of Familial Colorectal Cancer (U01 CA074783); Seattle Colorectal Cancer Family Registry (U01 CA074794); University of Hawaii Colorectal Cancer Family Registry (U01 CA074806); and University of California, Irvine Informatics Center (U01 CA078296). We thank Allyson Templeton for providing us with data on CCFR enrollment and follow-up. We also thank Sushma Thomas, Christine Rimorin, Jeanne DaGloria, and Ling-Yu Kuan of the FHCRC Molecular Epidemiology Laboratory for genotyping assistance.